One thing I’d like to start doing with the blog is a weekly “in the news” post. I was looking online today and ran across the following article from http://www.foxnews.com: Antidepressants, OTC Painkillers Not a Good Combination
Imagine you are working in fast track and you see a 50yo female with joint pain. Your assessment after you have talked with and examined the patient is that it is likely arthritis. You notice the patient has a past medical history of depression and is on Celexa. Your plan is to discharge the patient on naproxen. Is this a reasonable plan?
Prior to reading the article below I would have done this without thinking twice. I ran a drug interaction check between SSRIs and NSAIDs and only found an increased risk of bleeding, SIADH, and hyponatremia. Has anyone else heard of NSAIDs reducing the effectiveness of SSRIs? I know this isn’t journal club, but will knowing this change your practice?